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Characterisation of dendritic cells arising from progenitors endogenous to murine spleen

Petvises, Sawang; O’Neill, Helen C.


Heterogeneity amongst dendritic cell (DC) subsets leads to a spectrum of immune response capacity against pathogens. Several DC subsets in spleen have been described which differ in terms of phenotype and function. We have previously reported a distinct population of CD11c(lo)CD11b(hi)MHC-II(-)CD8(-) dendritic-like "L-DC" in murine spleen, which can also be generated in splenic stromal longterm cultures. Here, the ontogeny of L-DC development in perinatal mice has been compared with other known...[Show more]

CollectionsANU Research Publications
Date published: 2014-02-14
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0088311


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