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Promotion of mammalian angiogenesis by neolignans derived from soybean extracellular fluids

Kordbacheh, Farzaneh; Carruthers, Thomas; Bezos, Anna; Oakes, Marie; Du Fall, Lauren; Hocart, Charles; Parish, Christopher; Djordjevic, Michael

Description

Excessive or insufficient angiogenesis is associated with major classes of chronic disease. Although less studied, small molecules which can promote angiogenesis are being sought as potential therapeutics for cardiovascular and peripheral arterial disease and stroke. Here we describe a bioassay-directed discovery approach utilising size exclusion and liquid chromatography to purify components of soybean xylem sap that have pro-angiogenic activity. Using high resolution accurate mass...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164067
Source: PLOS ONE
DOI: 10.1371/journal.pone.0196843
Access Rights: Open Access

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