Immunoglobulin isotype switching ceases in germinal centres
B cell-derived antibodies are essential to protect against infection and underpin the success of most existing vaccines. Class switch recombination (CSR) is a tightly controlled DNA recombination that replaces the constant region of an antibody for the isotype that can best protect against the invading pathogen. Germinal centres (GCs) are thought to favour immunoglobulin (Ig) diversification through somatic hypermutation (SHM) and CSR at least in part because...[Show more]
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