The pantothenate kinase of the human malaria parasite Plasmodium falciparum
The intraerythrocytic stage of the malaria parasite Plasmodium falciparum has an absolute requirement for vitamin B5 (also known as pantothenate) in order to survive. The parasite takes up extracellular pantothenate and subsequently converts it into coenzyme A (CoA) via a series of five universal enzymatic steps. The first enzyme of the pathway is pantothenate kinase (PanK), which phosphorylates pantothenate and commits the molecule to CoA biosynthesis. There...[Show more]
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