Accurate Electron-Nucleus Distances from Paramagnetic Relaxation Enhancements
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Orton, Henry; Otting, Gottfried
Description
Measurements of paramagnetic relaxation enhancements (PREs) in 1H NMR spectra are an important tool to obtain long-range distance information in proteins, but quantitative interpretation is easily compromised by nonspecific intermolecular PREs. Here we show that PREs generated by lanthanides with anisotropic magnetic susceptibilities offer a route to accurate calibration-free distance measurements. As these lanthanides change 1H chemical shifts due to pseudocontact shifts, the relaxation rates...[Show more]
Collections | ANU Research Publications |
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Date published: | 2018 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/163971 |
Source: | Journal of the American Chemical Society |
DOI: | 10.1021/jacs.8b03858 |
Access Rights: | Open Access |
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jacs2018_140_7688_supp.pdf | 1.97 MB | Adobe PDF | ![]() |
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