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Accurate Electron-Nucleus Distances from Paramagnetic Relaxation Enhancements

Orton, Henry; Otting, Gottfried

Description

Measurements of paramagnetic relaxation enhancements (PREs) in 1H NMR spectra are an important tool to obtain long-range distance information in proteins, but quantitative interpretation is easily compromised by nonspecific intermolecular PREs. Here we show that PREs generated by lanthanides with anisotropic magnetic susceptibilities offer a route to accurate calibration-free distance measurements. As these lanthanides change 1H chemical shifts due to pseudocontact shifts, the relaxation rates...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/163971
Source: Journal of the American Chemical Society
DOI: 10.1021/jacs.8b03858
Access Rights: Open Access

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