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Spatiotemporal patterns of Japanese encephalitis in China, 2002–2010

Wang, Li-Ya; Zhang, Wen-Yi; Ding, Fan; Hu, Wen-Biao; Soares Magalhaes, Ricardo; Sun, Hai-Long; Li, Yi-Xing; Zou, Wen; Wang, Yong; Liu, Qi-Yong; Li, Shen-Long; Yin, Wen-Wu; Huang, Liu-Yu; Clements, Archie C. A.; Bi, Peng; Li, Cheng-Yi

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OBJECTIVE The aim of the study is to examine the spatiotemporal pattern of Japanese Encephalitis (JE) in mainland China during 2002-2010. Specific objectives of the study were to quantify the temporal variation in incidence of JE cases, to determine if clustering of JE cases exists, to detect high risk spatiotemporal clusters of JE cases and to provide evidence-based preventive suggestions to relevant stakeholders. METHODS Monthly JE cases at the county level in mainland China during 2002-2010...[Show more]

dc.contributor.authorWang, Li-Ya
dc.contributor.authorZhang, Wen-Yi
dc.contributor.authorDing, Fan
dc.contributor.authorHu, Wen-Biao
dc.contributor.authorSoares Magalhaes, Ricardo
dc.contributor.authorSun, Hai-Long
dc.contributor.authorLi, Yi-Xing
dc.contributor.authorZou, Wen
dc.contributor.authorWang, Yong
dc.contributor.authorLiu, Qi-Yong
dc.contributor.authorLi, Shen-Long
dc.contributor.authorYin, Wen-Wu
dc.contributor.authorHuang, Liu-Yu
dc.contributor.authorClements, Archie C. A.
dc.contributor.authorBi, Peng
dc.contributor.authorLi, Cheng-Yi
dc.date.accessioned2015-11-05T00:10:49Z
dc.date.available2015-11-05T00:10:49Z
dc.identifier.issn1935-2735
dc.identifier.urihttp://hdl.handle.net/1885/16352
dc.description.abstractOBJECTIVE The aim of the study is to examine the spatiotemporal pattern of Japanese Encephalitis (JE) in mainland China during 2002-2010. Specific objectives of the study were to quantify the temporal variation in incidence of JE cases, to determine if clustering of JE cases exists, to detect high risk spatiotemporal clusters of JE cases and to provide evidence-based preventive suggestions to relevant stakeholders. METHODS Monthly JE cases at the county level in mainland China during 2002-2010 were obtained from the China Information System for Diseases Control and Prevention (CISDCP). For the purpose of the analysis, JE case counts for nine years were aggregated into four temporal periods (2002; 2003-2005; 2006; and 2007-2010). Local Indicators of Spatial Association and spatial scan statistics were performed to detect and evaluate local high risk space-time clusters. RESULTS JE incidence showed a decreasing trend from 2002 to 2005 but peaked in 2006, then fluctuated over the study period. Spatial cluster analysis detected high value clusters, mainly located in Southwestern China. Similarly, we identified a primary spatiotemporal cluster of JE in Southwestern China between July and August, with the geographical range of JE transmission increasing over the past years. CONCLUSION JE in China is geographically clustered and its spatial extent dynamically changed during the last nine years in mainland China. This indicates that risk factors for JE infection are likely to be spatially heterogeneous. The results may assist national and local health authorities in the development/refinement of a better preventive strategy and increase the effectiveness of public health interventions against JE transmission.
dc.description.sponsorshipThis study was funded in part by the grants from National Basic Research Program of China (2012CB955500-955504) and National Natural Science Foundation of China (81102169), Special Grant for the Prevention and Control of Infectious Diseases (2012ZX1004801-002-007, 2013ZX10004218, and 2013ZX10004-203). RJSM is supported by a UQ Postdoctoral Fellowship.
dc.format8 pages
dc.publisherPublic Library of Science
dc.rights© 2013 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourcePLoS Neglected Tropical Diseases
dc.subjectchina
dc.subjectcluster analysis
dc.subjectencephalitis, japanese
dc.subjecthumans
dc.subjecttime factors
dc.subjecttopography, medical
dc.titleSpatiotemporal patterns of Japanese encephalitis in China, 2002–2010
dc.typeJournal article
local.description.notesImported from ARIES. At the time of publication, Archie C. A. Clements was affiliated with 3 School of Population Health, Infectious Disease Epidemiology Unit, The University of Queensland, Brisbane, Australia.
local.identifier.citationvolume7
dcterms.dateAccepted2013-05-10
dc.date.issued2013-06-20
local.identifier.absfor111706
local.identifier.ariespublicationU3488905xPUB4067
local.publisher.urlhttps://www.plos.org/
local.type.statusPublished Version
local.contributor.affiliationWang, Li-Ya, Academy of Military Medical Science, China
local.contributor.affiliationZhang, Wen-Yi, Academy of Military Medical Science, China
local.contributor.affiliationDing, Fan, Chinese Center for Disease Control and Prevention, China
local.contributor.affiliationHu, Wen-Biao, University of Queensland, Australia
local.contributor.affiliationMagalhaes, Ricardo, University of Queensland, Australia
local.contributor.affiliationSun, Hai-Long, Academy of Military Medical Science, China
local.contributor.affiliationLi, Yi-Xing, Chinese Centre for Disease Control and Prevention, China
local.contributor.affiliationZou, Wen, Chinese Academy of Military Science, China
local.contributor.affiliationWang, Yong, Chinese Academy of Military Medical Science, China
local.contributor.affiliationLiu, Qi-Yong, Chinese Center for Disease Control and Prevention, China
local.contributor.affiliationClements, Archie, College of Medicine, Biology and Environment, CMBE Research School of Population Health, Natl Centre for Epidemiology & Population Health, The Australian National University
local.identifier.essn1935-2735
local.bibliographicCitation.issue6
local.bibliographicCitation.startpagee2285
local.bibliographicCitation.lastpage8
local.identifier.doi10.1371/journal.pntd.0002285
dc.date.updated2015-12-11T08:41:04Z
local.identifier.scopusID2-s2.0-84879520908
CollectionsANU Research Publications

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