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Shigella flexneri infection in Caenorhabditis elegans: cytopathological examination and identification of host responses

George, Divya T.; Behm, Carolyn A.; Hall, David H.; Mathesius, Ulrike; Rug, Melanie; Nguyen, Ken C. Q.; Verma, Naresh K.


The Gram-negative bacterium Shigella flexneri is the causative agent of shigellosis, a diarrhoeal disease also known as bacillary dysentery. S. flexneri infects the colonic and rectal epithelia of its primate host and induces a cascade of inflammatory responses that culminates in the destruction of the host intestinal lining. Molecular characterization of host-pathogen interactions in this infection has been challenging due to the host specificity of S. flexneri strains, as it strictly infects...[Show more]

CollectionsANU Research Publications
Date published: 2014-09-04
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0106085


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