Relationship between lifestyle and health factors and severe lower urinary tract symptoms (LUTS) in 106,435 middle-aged and older Australian men: population-based study
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Smith, David P.; Weber, Marianne F.; Soga, Kay; Korda, Rosemary; Tikellis, Gabriella; Patel, Manish I.; Clements, Mark S.; Dwyer, Terry; Latz, Isabel K.; Banks, Emily
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BACKGROUND Despite growing interest in prevention of lower urinary tract symptoms (LUTS) through better understanding of modifiable risk factors, large-scale population-based evidence is limited. OBJECTIVE To describe risk factors associated with severe LUTS in the 45 and Up Study, a large cohort study. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional analysis of questionnaire data from 106,435 men aged ≥ 45 years, living in New South Wales, Australia. OUTCOME MEASURES AND STATISTICAL...[Show more]
dc.contributor.author | Smith, David P. | |
---|---|---|
dc.contributor.author | Weber, Marianne F. | |
dc.contributor.author | Soga, Kay | |
dc.contributor.author | Korda, Rosemary | |
dc.contributor.author | Tikellis, Gabriella | |
dc.contributor.author | Patel, Manish I. | |
dc.contributor.author | Clements, Mark S. | |
dc.contributor.author | Dwyer, Terry | |
dc.contributor.author | Latz, Isabel K. | |
dc.contributor.author | Banks, Emily | |
dc.date.accessioned | 2015-11-03T23:32:11Z | |
dc.date.available | 2015-11-03T23:32:11Z | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/1885/16310 | |
dc.description.abstract | BACKGROUND Despite growing interest in prevention of lower urinary tract symptoms (LUTS) through better understanding of modifiable risk factors, large-scale population-based evidence is limited. OBJECTIVE To describe risk factors associated with severe LUTS in the 45 and Up Study, a large cohort study. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional analysis of questionnaire data from 106,435 men aged ≥ 45 years, living in New South Wales, Australia. OUTCOME MEASURES AND STATISTICAL ANALYSIS LUTS were measured by a modified version of the International Prostate Symptom Score (m-IPSS). The strength of association between severe LUTS and socio-demographic, lifestyle and health-related factors was estimated, using logistic regression to calculate odds ratios, adjusted for a range of confounding factors. RESULTS Overall, 18.3% reported moderate, and 3.6% severe, LUTS. Severe LUTS were more common among men reporting previous prostate cancer (7.6%), total prostatectomy (4.9%) or having part of the prostate removed (8.2%). After excluding men with prostate cancer or prostate surgery, the prevalence of moderate-severe LUTS in the cohort (n = 95,089) ranged from 10.6% to 35.4% for ages 45-49 to ≥ 80; the age-related increase was steeper for storage than voiding symptoms. The adjusted odds of severe LUTS decreased with increasing education (tertiary qualification versus no school certificate, odds ratio (OR = 0.78 (0.68-0.89))) and increasing physical activity (high versus low, OR = 0.83 (0.76-0.91)). Odds were elevated among current smokers versus never-smokers (OR = 1.64 (1.43-1.88)), obese versus healthy-weight men (OR = 1.27 (1.14-1.41)) and for comorbid conditions (e.g., heart disease versus no heart disease, OR = 1.36 (1.24-1.49)), and particularly for severe versus no physical functional limitation (OR = 5.17 (4.51-5.93)). CONCLUSIONS LUTS was associated with a number of factors, including modifiable risk factors, suggesting potential targets for prevention. | |
dc.description.sponsorship | DPS (APP1016598) and EB (APP1042717) are supported by the National Health and Medical Research Council of Australia, https://www.nhmrc.gov.au/. This project was supported in part by a JM O’Hara Grant from the Pharmaceutical Society of Western Australia, http://www.pswa.org.au/, and by a National Health and Medical Research Council of Australia project grant (APP1024450). | |
dc.format | 10 pages | |
dc.publisher | Public Library of Science | |
dc.rights | © 2014 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.source | PLoS ONE | |
dc.subject | aged | |
dc.subject | aged, 80 and over | |
dc.subject | australia | |
dc.subject | cohort studies | |
dc.subject | cross-sectional studies | |
dc.subject | health surveys | |
dc.subject | humans | |
dc.subject | lower urinary tract symptoms | |
dc.subject | male | |
dc.subject | middle aged | |
dc.subject | prevalence | |
dc.subject | prostatectomy | |
dc.subject | prostatic neoplasms | |
dc.subject | questionnaires | |
dc.subject | risk factors | |
dc.subject | severity of illness index | |
dc.subject | life style | |
dc.title | Relationship between lifestyle and health factors and severe lower urinary tract symptoms (LUTS) in 106,435 middle-aged and older Australian men: population-based study | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 9 | |
dcterms.dateAccepted | 2014-08-29 | |
dc.date.issued | 2014-10-15 | |
local.identifier.absfor | 111706 | |
local.identifier.ariespublication | U3488905xPUB4764 | |
local.publisher.url | https://www.plos.org/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Smith, David, Cancer Council NSW, Australia | |
local.contributor.affiliation | Weber, Marianne R, Griffith University, Australia | |
local.contributor.affiliation | Soga, Kay, College of Medicine, Biology and Environment, CMBE Research School of Population Health, Natl Centre for Epidemiology & Population Health, The Australian National University | |
local.contributor.affiliation | Korda, Rosemary, College of Medicine, Biology and Environment, CMBE Research School of Population Health, Natl Centre for Epidemiology & Population Health, The Australian National University | |
local.contributor.affiliation | Tikellis, Gabriella, Murdoch Children's Research Institute, Australia | |
local.contributor.affiliation | Patel, Manish, The University of Sydney, Australia | |
local.contributor.affiliation | Clements, Mark S, Karolinska Institute, Sweden | |
local.contributor.affiliation | Dwyer, Terry, Murdoch Children's Research Institute, Australia | |
local.contributor.affiliation | Latz, Isabel, University of California, United States of America | |
local.contributor.affiliation | Banks, Emily, College of Medicine, Biology and Environment, CMBE Research School of Population Health, Natl Centre for Epidemiology & Population Health, The Australian National University | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1016598 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1042717 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1024450 | |
local.identifier.essn | 1932-6203 | |
local.bibliographicCitation.issue | 10 | |
local.bibliographicCitation.startpage | e109278 | |
local.bibliographicCitation.lastpage | 10 | |
local.identifier.doi | 10.1371/journal.pone.0109278 | |
dc.date.updated | 2015-12-11T09:10:26Z | |
local.identifier.scopusID | 2-s2.0-84908029024 | |
local.identifier.thomsonID | 000346766200020 | |
Collections | ANU Research Publications |
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