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Increased antigen specific T cell numbers in the absence of altered migration or division rates as a result of mucosal cholera toxin administration

Kaparakis-Liaskos, Maria; Tate, Michelle D.; Price, Jason D.; Pearse, Martin; Wijburg, Odilia L. C.


Cholera toxin (CT) is a mucosal adjuvant capable of inducing strong immune responses to co-administered antigens following oral or intranasal immunization of mice. To date, the direct effect of CT on antigen-specific CD4(+) T cell migration and proliferation profiles in vivo is not well characterized. In this study, the effect of CT on the migration pattern and proliferative responses of adoptively transferred, CD4(+) TCR transgenic T cells in orally or intranasally vaccinated mice, was...[Show more]

CollectionsANU Research Publications
Date published: 2013-03-27
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0059934


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