VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice
Damsker, Jesse M.; Dillingham, Blythe C.; Rose, Mary C.; Balsley, Molly A.; Heier, Christopher; Watson, Alan M.; Stemmy, Erik J.; Jurjus, Roslyn A.; Huynh, Tony; Tatem, Kathleen; Uaesoontrachoon, Kitipong; Berry, Dana M.; Benton, Angela S.; Freishtat, Robert J.; Hoffman, Eric P.; McCall, John M.; Gordish-Dressman, Heather; Constant, Stephanie L.; Reeves, Erica K. M.; Nagaraju, Kanneboyina
Asthma is a chronic inflammatory condition of the lower respiratory tract associated with airway hyperreactivity and mucus obstruction in which a majority of cases are due to an allergic response to environmental allergens. Glucocorticoids such as prednisone have been standard treatment for many inflammatory diseases for the past 60 years. However, despite their effectiveness, long-term treatment is often limited by adverse side effects believed to be caused by glucocorticoid receptor-mediated...[Show more]
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