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Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function

Humphreys, David T.; Hynes, Carly J.; Patel, Hardip R.; Wei, Grace H.; Cannon, Leah; Fatkin, Diane; Suter, Catherine M.; Clancy, Jennifer L.; Preiss, Thomas


microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants. We subjected small RNA from murine HL-1 cardiomyocyte cells to next generation sequencing to investigate the relevance of such diversity to cardiac biology. ∼40 million tags were mapped to known miRNA hairpin sequences as deposited in miRBase version 16, calling 403 generic miRNAs as appreciably expressed....[Show more]

CollectionsANU Research Publications
Date published: 2012-02-03
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0030933


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