Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function
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Humphreys, David T.; Hynes, Carly J.; Patel, Hardip R.; Wei, Grace H.; Cannon, Leah; Fatkin, Diane; Suter, Catherine M.; Clancy, Jennifer L.; Preiss, Thomas
Description
microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants. We subjected small RNA from murine HL-1 cardiomyocyte cells to next generation sequencing to investigate the relevance of such diversity to cardiac biology. ∼40 million tags were mapped to known miRNA hairpin sequences as deposited in miRBase version 16, calling 403 generic miRNAs as appreciably expressed....[Show more]
Collections | ANU Research Publications |
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Date published: | 2012-02-03 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/16138 |
Source: | PLoS ONE |
DOI: | 10.1371/journal.pone.0030933 |
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01_Humphreys_Complexity_of_murine_2012.pdf | Published Version | 1.71 MB | Adobe PDF |
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