Skip navigation
Skip navigation

Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function

Humphreys, David T.; Hynes, Carly J.; Patel, Hardip R.; Wei, Grace H.; Cannon, Leah; Fatkin, Diane; Suter, Catherine M.; Clancy, Jennifer L.; Preiss, Thomas


microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants. We subjected small RNA from murine HL-1 cardiomyocyte cells to next generation sequencing to investigate the relevance of such diversity to cardiac biology. ∼40 million tags were mapped to known miRNA hairpin sequences as deposited in miRBase version 16, calling 403 generic miRNAs as appreciably expressed....[Show more]

CollectionsANU Research Publications
Date published: 2012-02-03
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0030933


File Description SizeFormat Image
01_Humphreys_Complexity_of_murine_2012.pdfPublished Version1.71 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator