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Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers

Sharma, Pooja; Pandey, Rinku; Kumari, Kirti; Pandey, Gunjan; Jackson, Colin J; Russell, Robyn J; Oakeshott, John Graham; Lal, Rup


BACKGROUND Here we report specific activities of all seven naturally occurring LinA variants towards three different isomers, α, γ and δ, of a priority persistent pollutant, hexachlorocyclohexane (HCH). Sequence-structure-function differences contributing to the differences in their stereospecificity for α-, γ-, and δ-HCH and enantiospecificity for (+)- and (-)-α -HCH are also discussed. METHODOLOGY/PRINCIPAL FINDINGS Enzyme kinetic studies were performed with purified LinA variants. Models of...[Show more]

CollectionsANU Research Publications
Date published: 2011-09-16
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0025128


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