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Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera

Biswas, Sunita; Russell, Robyn J; Jackson, Colin J; Vidovic, Maria; Ganeshina, Olga; Oakeshott, John Graham; Claudianos, Charles


Vertebrate studies show neuroligins and neurexins are binding partners in a trans-synaptic cell adhesion complex, implicated in human autism and mental retardation disorders. Here we report a genetic analysis of homologous proteins in the honey bee. As in humans, the honeybee has five large (31-246 kb, up to 12 exons each) neuroligin genes, three of which are tightly clustered. RNA analysis of the neuroligin-3 gene reveals five alternatively spliced transcripts, generated through alternative...[Show more]

CollectionsANU Research Publications
Date published: 2008-10-31
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0003542


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