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Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance

Stevenson, Bradley J.; Pignatelli, Patricia; Nikou, Dimitra; Paine, Mark J. I.


BACKGROUND Pyrethroids are increasingly used to block the transmission of diseases spread by Aedes aegypti such as dengue and yellow fever. However, insecticide resistance poses a serious threat, thus there is an urgent need to identify the genes and proteins associated with pyrethroid resistance in order to produce effective counter measures. In Ae. aegypti, overexpression of P450s such as the CYP9J32 gene have been linked with pyrethroid resistance. Our aim was to confirm the role of CYP9J32...[Show more]

CollectionsANU Research Publications
Date published: 2012-03-27
Type: Journal article
Source: PLoS Neglected Tropical Diseases
DOI: 10.1371/journal.pntd.0001595


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