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Field-caught permethrin-resistant anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids

Müller, Pie; Warr, Emma; Stevenson, Bradley J.; Pignatelli, Patricia M.; Morgan, John C.; Steven, Andrew; Yawson, Alexander E.; Mitchell, Sara N.; Ranson, Hilary; Hemingway, Janet; Paine, Mark J. I.; Donnelly, Martin J.


Insects exposed to pesticides undergo strong natural selection and have developed various adaptive mechanisms to survive. Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing attention because it threatens the sustainability of malaria vector control programs in sub-Saharan Africa. An understanding of the molecular mechanisms conferring pyrethroid resistance gives insight into the processes of evolution of adaptive traits and facilitates the...[Show more]

CollectionsANU Research Publications
Date published: 2008-11-28
Type: Journal article
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.1000286


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