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The intracellular HBV DNAs as novel and sensitive biomarkers for the clinical diagnosis of occult HBV infection in HBeAg negative hepatocellular carcinoma in China

Wang, Hui; Fang, Meng; Gu, Xing; Ji, Qiang; Li, Dongdi; Cheng, Shu-Qun; Shen, Feng; Gao, Chun-Fang

Description

This study aimed to investigate the virological status in liver (both tumor and adjacent non-tumor tissue), the clinical features and the contribution of occult HBV infection (OBI) to postoperative prognosis in HBeAg-negative(-) hepatocellular carcinoma (HCC) patients in China. Using quantitative TaqMan fluorescent real-time PCR assays, HBV covalently closed circular DNA (cccDNA) and total DNA (tDNA) were both quantified in 11 (HBsAg(-)) and 57 (HBsAg-positive(+)) pairs of tumor tissue (TT) and...[Show more]

CollectionsANU Research Publications
Date published: 2014-09-17
Type: Journal article
URI: http://hdl.handle.net/1885/16110
Source: PLoS ONE
DOI: 10.1371/journal.pone.0107162

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