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Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway

Furuya, Yoichi; Chan, Jennifer; Wan, En-Chi; Koskinen, Aulikki; Diener, Kerrilyn R.; Hayball, John D.; Regner, Matthias; Müllbacher, Arno; Alsharifi, Mohammed


BACKGROUND We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but not CD25. This partial lymphocytes activation is mediated by type-I interferons (IFN-I). Importantly, we have shown that γ-irradiated SFV does not induce IFN-I and the associated lymphocyte activation. PRINCIPAL FINDINGS Here we report that, in...[Show more]

CollectionsANU Research Publications
Date published: 2011-10-05
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0025765


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