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Neuronal microRNA eeregulation in response to Alzheimer's disease Amyloid-β

Schonrock, Nicole; Ke, Yazi D.; Humphreys, David; Staufenbiel, Matthias; Ittner, Lars M.; Preiss, Thomas; Götz, Jürgen

Description

Normal brain development and function depends on microRNA (miRNA) networks to fine tune the balance between the transcriptome and proteome of the cell. These small non-coding RNA regulators are highly enriched in brain where they play key roles in neuronal development, plasticity and disease. In neurodegenerative disorders such as Alzheimer's disease (AD), brain miRNA profiles are altered; thus miRNA dysfunction could be both a cause and a consequence of disease. Our study dissects the...[Show more]

CollectionsANU Research Publications
Date published: 2010-06-11
Type: Journal article
URI: http://hdl.handle.net/1885/16093
Source: PLoS ONE
DOI: 10.1371/journal.pone.0011070

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