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microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells

Beilharz, Traude H.; Humphreys, David T.; Clancy, Jennifer L.; Thermann, Rolf; Martin, David I. K.; Hentze, Matthias W.; Preiss, Thomas


Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3' untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability. They also commonly induce shortening of the mRNA 3' poly(A) tail, which contributes to their mRNA decay promoting function. The relationship between miRNA-mediated deadenylation and translational repression has been less clear. Using transfection of reporter constructs carrying three...[Show more]

CollectionsANU Research Publications
Date published: 2009-08-27
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0006783


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