Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer
While new cancer treatments continue to improve patient outcomes, for some cancers there have been limited or no improvements for a long time. It is for these cases radically new approaches are required. Recent publications proposing ribosome biogenesis, in particular RNA polymerase I transcription, as a suitable target for cancer treatment has been gaining momentum. For example, we demonstrated that CX-5461, a specific RNA polymerase I transcription inhibitor, is effective in treating an...[Show more]
|Collections||ANU Research Publications|
|Source:||Technology in Cancer Research and Treatment|
|01_Hein_Inhibition_of_Pol_I_2017.pdf||241.96 kB||Adobe PDF|
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