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Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer

Hein, Nadine; Hannan, Katherine; D'Rozario, James; Hannan, Ross


While new cancer treatments continue to improve patient outcomes, for some cancers there have been limited or no improvements for a long time. It is for these cases radically new approaches are required. Recent publications proposing ribosome biogenesis, in particular RNA polymerase I transcription, as a suitable target for cancer treatment has been gaining momentum. For example, we demonstrated that CX-5461, a specific RNA polymerase I transcription inhibitor, is effective in treating an...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Technology in Cancer Research and Treatment
DOI: 10.1177/1533034617744955
Access Rights: Open Access


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