Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer
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Hein, Nadine; Hannan, Katherine; D'Rozario, James; Hannan, Ross
Description
While new cancer treatments continue to improve patient outcomes, for some cancers there have been limited or no improvements for a long time. It is for these cases radically new approaches are required. Recent publications proposing ribosome biogenesis, in particular RNA polymerase I transcription, as a suitable target for cancer treatment has been gaining momentum. For example, we demonstrated that CX-5461, a specific RNA polymerase I transcription inhibitor, is effective in treating an...[Show more]
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/160895 |
Source: | Technology in Cancer Research and Treatment |
DOI: | 10.1177/1533034617744955 |
Access Rights: | Open Access |
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