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3D mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle Cryo-EM

Perálvarez-Marín, Alex; Tae, HanShen; Board, Philip G.; Casarotto, Marco G.; Dulhunty, Angela F.; Samsó, Montserrat


The type 1 skeletal muscle ryanodine receptor (RyR1) is principally responsible for Ca(2+) release from the sarcoplasmic reticulum and for the subsequent muscle contraction. The RyR1 contains three SPRY domains. SPRY domains are generally known to mediate protein-protein interactions, however the location of the three SPRY domains in the 3D structure of the RyR1 is not known. Combining immunolabeling and single-particle cryo-electron microscopy we have mapped the SPRY2 domain (S1085-V1208) in...[Show more]

CollectionsANU Research Publications
Date published: 2011-10-05
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0025813


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