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Genome-wide analysis of chemically induced mutations in mouse in phenotype-driven screens

Bauer, Denis C.; McMorran, Brendan J.; Foote, Simon J.; Burgio, Gaetan

Description

BACKGROUND: N-ethyl-N-nitrosourea (ENU) mutagen has become the method of choice for inducing random mutations for forward genetics applications. However, distinguishing induced mutations from sequencing errors or sporadic mutations is difficult, which has hampered surveys of potential biases in the methodology in the past. Addressing this issue, we created a large cohort of mice with biological replicates enabling the confident calling of induced mutations, which in turn...[Show more]

CollectionsANU Research Publications
Date published: 2015-10-26
Type: Journal article
URI: http://hdl.handle.net/1885/16087
Source: BMC Genomics
DOI: 10.1186/s12864-015-2073-4

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