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Regulation of Peptide Hormones.

Gu, Chen

Description

C-Terminal amidated peptide hormones regulate numerous physiological process and are associated with many pathological conditions. Their C-terminal amidation is exclusively catalysed by the enzyme peptidylglycine alpha-amidating monooxygenase (PAM), which has two subunits: peptidylglycine alpha-hydroxylating monooxygenase (PHM; EC 1.14.17.3) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL; EC 4.3.2.5). In the present study, the substrate specificity and inhibition of the PAM...[Show more]

CollectionsOpen Access Theses
Date published: 2019
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/160834
DOI: 10.25911/5d5148f06d829

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