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Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis

Jones, Anderson P; Trend, Stephanie; Byrne, Scott N.; Fabis-Pedrini, Marzena J; Geldenhuys, Sian; Nolan, David; Booth, David R; Carroll, WM; Lucas, Robyn; Kermode, AG; Hart, Prue


Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n = 18 treatment-naive individuals with recently diagnosed CIS (< 120 days) for disturbances in the phenotype of T regulatory (Treg), follicular T regulatory (Tfr), T helper (Th), follicular T helper...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Clinical and Translational Immunology
DOI: 10.1038/cti.2017.18
Access Rights: Open Access


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