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DNA-dependent protein kinase inhibits AID-induced antibody gene conversion

Cook, Adam J. L.; Raftery, Joanna M.; Lau, K. K. Edwin; Jessup, Andrew; Harris, Reuben S.; Takeda, Shunichi; Jolly, Christopher J.


Affinity maturation and class switching of antibodies requires activation-induced cytidine deaminase (AID)-dependent hypermutation of Ig V(D)J rearrangements and Ig S regions, respectively, in activated B cells. AID deaminates deoxycytidine bases in Ig genes, converting them into deoxyuridines. In V(D)J regions, subsequent excision of the deaminated bases by uracil-DNA glycosylase, or by mismatch repair, leads to further point mutation or gene conversion, depending on the species. In Ig S...[Show more]

CollectionsANU Research Publications
Date published: 2007-03-13
Type: Journal article
Source: PLoS Biology
DOI: 10.1371/journal.pbio.0050080


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