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Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase

Wojtasz, Lukasz; Daniel, Katrin; Roig, Ignasi; Bolcun-Filas, Ewelina; Xu, Huiling; Boonsanay, Verawan; Eckmann, Christian R.; Cooke, Howard J.; Jasin, Maria; Keeney, Scott; McKay, Michael J.; Toth, Attila


Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are repaired by recombination from homologous chromosomes (homologues). In a wide variety of organisms, meiotic HORMA-domain proteins are required to direct DSB repair towards homologues. This inter-homologue bias is required for efficient homology search, homologue alignment, and crossover formation. HORMA-domain proteins are also implicated in other processes related to crossover formation, including DSB formation,...[Show more]

CollectionsANU Research Publications
Date published: 2009-10-23
Type: Journal article
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.1000702


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