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Novel anti-metastatic action of Cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV+ tumor cells

Amine, Abdessamad; Rivera, Sofia; Opolon, Paule; Dekkal, Mehdi; Biard, Denis S. F.; Bouamar, Hakim; Louache, Fawzia; McKay, Michael J.; Bourhis, Jean; Deutsch, Eric; Vozenin-Brotons, Marie-Catherine


Cervical cancer is frequently associated with HPV infection. The expression of E6 and E7 HPV oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. The cellular mechanisms involved in metastatic spread remain elusive, but pro-adhesive receptors and their ligands, such as SDF-1alpha and CXCR4 are implicated. In the present study, we assessed the possible relationship between SDF-1alpha/CXCR4 signaling, E6/E7 status and the...[Show more]

CollectionsANU Research Publications
Date published: 2009-03-26
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0005018


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