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Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells

Tze, Lina E.; Schram, Brian R.; Lam, Kong-Peng; Hogquist, Kristin A.; Hippen, Keli L.; Liu, Jiabin; Shinton, Susan A.; Otipoby, Kevin L.; Rodine, Peter R.; Vegoe, Amanda L.; Kraus, Manfred; Hardy, Richard R.; Schlissel, Mark S.; Rajewsky, Klaus; Behrens, Timothy W.


In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B stage. A subsequent functional light chain (LC) rearrangement then results in the surface expression of IgM at the immature B cell stage. Here we show that interruption of basal IgM signaling in immature B cells, either by the inducible deletion of surface Ig via Cre-mediated excision or by incubating...[Show more]

CollectionsANU Research Publications
Date published: 2005-03-08
Type: Journal article
Source: PLoS Biology
DOI: 10.1371/journal.pbio.0030082


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