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Smoking in the family is most predictive of the development of childhood asthma in preterm babies < 30 weeks gestation: Results of the Respiratory Outcomes Study 2 (RESPOS2)

Johnston, Claire; Broom, Margaret; Shadbolt, Bruce; Todd, David

Description

Objectives: The Respiratory Outcomes Study 2 (RESPOS2) investigated the relationship between neonatal outcomes (specifically, chronic lung disease [CLD]) and environmental factors on the development of asthma and atopic outcomes at primary school age for preterm babies (PBs) <30 weeks gestational age (GA). Methods: The study included all surviving PBs <30 weeks GA admitted to the Neonatal Intensive Care Unit at Canberra Hospital, Australian Capital Territory between 2007 and 2009. Parents were...[Show more]

dc.contributor.authorJohnston, Claire
dc.contributor.authorBroom, Margaret
dc.contributor.authorShadbolt, Bruce
dc.contributor.authorTodd, David
dc.date.accessioned2019-04-24T06:04:58Z
dc.identifier.issn0277-0903
dc.identifier.urihttp://hdl.handle.net/1885/160652
dc.description.abstractObjectives: The Respiratory Outcomes Study 2 (RESPOS2) investigated the relationship between neonatal outcomes (specifically, chronic lung disease [CLD]) and environmental factors on the development of asthma and atopic outcomes at primary school age for preterm babies (PBs) <30 weeks gestational age (GA). Methods: The study included all surviving PBs <30 weeks GA admitted to the Neonatal Intensive Care Unit at Canberra Hospital, Australian Capital Territory between 2007 and 2009. Parents were sent a questionnaire regarding asthma and atopy symptoms when the PBs were aged 5–7 years old. Data were compared based on CLD status. Results: There were 103 PBs included in the study with a 68.9% response rate to the respiratory questionnaire (71/103). Of these PBs, 15/71 (21.1%) received a diagnosis of CLD. There were no significant differences with regards to asthma, hay fever or eczema in PBs either with or without CLD. The most significant predictor for the development of asthma was smoking in the family (Odds Ratio [OR]: 11.66, 95% Confidence Interval [CI]: 2.01–67.56) with a trend toward significance for family history of asthma (OR: 3.83, 95% CI: 0.85–17.25). Conclusion: The RESPOS2 has confirmed previous reports that CLD in PBs <30 weeks GA is not associated with the development of childhood asthma, hay fever or eczema. In our group of PBs, the strongest predictor of the development of asthma was smoking in the family.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherMarcel Dekker Inc.
dc.rights© Taylor & Francis Group, LLC
dc.sourceJournal of Asthma
dc.titleSmoking in the family is most predictive of the development of childhood asthma in preterm babies < 30 weeks gestation: Results of the Respiratory Outcomes Study 2 (RESPOS2)
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume55
dc.date.issued2018
local.identifier.absfor110203 - Respiratory Diseases
local.identifier.absfor111401 - Foetal Development and Medicine
local.identifier.ariespublicationu4485658xPUB2426
local.publisher.urlhttps://www.routledge.com/
local.type.statusPublished Version
local.contributor.affiliationJohnston, Claire, College of Health and Medicine, ANU
local.contributor.affiliationBroom, Margaret, Department of Neonatology
local.contributor.affiliationShadbolt, Bruce, Canberra Hospital
local.contributor.affiliationTodd, David, College of Health and Medicine, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage705
local.bibliographicCitation.lastpage711
local.identifier.doi10.1080/02770903.2017.1366508
local.identifier.absseo920115 - Respiratory System and Diseases (incl. Asthma)
local.identifier.absseo920501 - Child Health
dc.date.updated2019-03-12T07:34:31Z
local.identifier.scopusID2-s2.0-85031503983
local.identifier.thomsonID000435118800002
CollectionsANU Research Publications

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