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The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

Alhallaf, Rafid; Agha, Zainab; Miller, Catherine M; Robertson, Avril; Sotillo, Javier; Croese, John; Cooper, Matthew A.; Masters, Seth; Kupz, Andreas; Smith, Nicholas; Loukas, Alex


Inflammasomes promote immunity to microbial pathogens by regulating the function of IL-1-family cytokines such as IL-18 and IL-1 beta. However, the roles for inflammasomes during parasitic helminth infections remain unclear. We demonstrate that mice and humans infected with gastrointestinal nematodes display increased IL-18 secretion, which in Trichuris-infected or worm antigen-treated mice and in macrophages co-cultured with Trichuris antigens or exosome-like vesicles was dependent on the...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Cell Reports
DOI: 10.1016/j.celrep.2018.03.097
Access Rights: Open Access


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