Decarboxylative couplings as versatile tools for late-stage peptide modifications
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While strategies for the late‐stage modification of peptides are crucial to the design and synthesis of new peptide‐based materials and therapeutics, synthetic methods have historically focused on the modification of select, nucleophilic amino acids. This review highlights decarboxylative coupling strategies as emerging tools for the targeted functionalization of native peptidic acids—α‐carboxylic acids and aspartic/glutamic acid residues—through complexity building CC and Cheteroatom bond...[Show more]
dc.contributor.author | Malins, Lara | |
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dc.date.accessioned | 2019-04-20T11:03:49Z | |
dc.identifier.issn | 2475-8817 | |
dc.identifier.uri | http://hdl.handle.net/1885/160519 | |
dc.description.abstract | While strategies for the late‐stage modification of peptides are crucial to the design and synthesis of new peptide‐based materials and therapeutics, synthetic methods have historically focused on the modification of select, nucleophilic amino acids. This review highlights decarboxylative coupling strategies as emerging tools for the targeted functionalization of native peptidic acids—α‐carboxylic acids and aspartic/glutamic acid residues—through complexity building CC and Cheteroatom bond formations. Decarboxylation strategies employing both activated carboxylic acids (redox‐active esters) and the direct application of unprotected carboxylic acids are discussed. Emphasis is placed on the scope and limitations of the methodologies as well as their compatibility with complex peptide substrates. | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | John Wiley & Sons Inc. | |
dc.source | Peptide Science | |
dc.title | Decarboxylative couplings as versatile tools for late-stage peptide modifications | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 110 | |
dc.date.issued | 2018 | |
local.identifier.absfor | 030503 - Organic Chemical Synthesis | |
local.identifier.ariespublication | u4485658xPUB2033 | |
local.type.status | Published Version | |
local.contributor.affiliation | Malins, Lara, College of Science, ANU | |
local.description.embargo | 2040-01-01 | |
local.bibliographicCitation.issue | 3 | |
local.identifier.doi | 10.1002/pep2.24049 | |
local.identifier.absseo | 970103 - Expanding Knowledge in the Chemical Sciences | |
dc.date.updated | 2019-03-12T07:32:24Z | |
local.identifier.thomsonID | 000434980800005 | |
dc.provenance | Journal: Peptide Science [See also associated title Biopolymers] RoMEO: This is a RoMEO yellow journal Paid OA: A paid open access option is available for this journal. Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: grey tick subject to Restrictions below, author can archive post-print (ie final draft post-refereeing) Restrictions: 12 months embargo Publisher's Version/PDF: cross author cannot archive publisher's version/PDF | |
Collections | ANU Research Publications |
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