Total Synthesis of Natural Hyacinthacine C-5 and Six Related Hyacinthacine C-5 Epimers
The total synthesis of natural (+)-hyacinthacine C-5 was achieved, which allowed correction of its initially proposed structure, as well as six additional hyacinthacine C-type compounds. These compounds were readily accessible from two epimeric anti-1,2-amino alcohols. Keeping a common A-ring configuration, chemical manipulation occurred selectively on the B-ring of the hyacinthacine C-type products through methods of syn-dihydroxylation, S(N)2 ring-opening of a cyclic sulfate, and also...[Show more]
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|Source:||Journal of Organic Chemistry|
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