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An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme

Esquirol, Lygie; Peat, Thomas S.; Wilding, Matthew; Liu, Jian-Wei; French, Nigel; Hartley, Carol J.; Onagi, Hideki; Nebl, Thomas; Easton, Christopher; Newman, Janet; Scott, Colin


Cyanuric acid is a metabolic intermediate of s-triazines, such as atrazine (a common herbicide) and melamine (used in resins and plastics). Cyanuric acid is mineralized to ammonia and carbon dioxide by the soil bacterium Pseudomonas sp. strain ADP via three hydrolytic enzymes (AtzD, AtzE, and AtzF). Here, we report the purification and biochemical and structural characterization of AtzE. Contrary to previous reports, we found that AtzE is not a biuret amidohydrolase, but instead it catalyzes...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.RA118.001996


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