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Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries: A protocol for a prospective observational study

Chan, Jocelyn; Nguyen, Cattram D; Lai, Jana Y R; Dunne, Eileen; Andrews, Ross; Blyth, Christopher C; Datta, Siddhartha; Fox, Kim; Ford, Rebecca; Hinds, Jason; La Vincente, Sophie


Introduction: Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: BMJ Open
DOI: 10.1136/bmjopen-2018-021512
Access Rights: Open Access


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