Skip navigation
Skip navigation

Computer-Guided Surface Engineering for Enzyme Improvement

Wilding, Matthew; Scott, Colin; Warden, Andrew

Description

Protein engineering strategies are often guided by our understanding of how the structure of a protein determines its function. However, our understanding is generally restricted to small regions of a protein, namely the active site and its immediate vicinity, while the remainder of the protein is something of an enigma. Studying highly homologous transaminases with strictly conserved active sites, but different substrate preferences and activities, we predict and experimentally validate that...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/160440
Source: Scientific Reports
DOI: 10.1038/s41598-018-30434-5
Access Rights: Open Access

Download

File Description SizeFormat Image
01_Wilding_Computer-Guided_Surface_2018.pdf1.48 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator