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Identification of cryptic subunits from an apicomplexan ATP synthase

Huet, Diego; Rajendran, Esther; van Dooren, Giel; Lourido, Sebastian

Description

The mitochondrial ATP synthase is a macromolecular motor that uses the proton gradient to generate ATP. Proper ATP synthase function requires a stator linking the catalytic and rotary portions of the complex. However, sequence-based searches fail to identify genes encoding stator subunits in apicomplexan parasites like Toxoplasma gondii or the related organisms that cause malaria. Here, we identify 11 previously unknown subunits from the Toxoplasma ATP synthase, which lack homologs outside the...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/160406
Source: eLife
DOI: 10.7554/eLife.38097
Access Rights: Open Access

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