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Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes

Davis, Kimberley J; Assadawi, Nawal M O; Pham, Son Q T; Birrento, Monica L; Richardson, Christopher; Beck, Jennifer; Willis, Anthony; Ralph, Stephen F


Two different series of nickel Schiff base complexes were prepared as part of a study aimed at discovering new compounds with high affinity and selectivity for quadruplex DNA (qDNA). The new complexes were prepared by modification of a literature method for synthesising N,N-bis-(4-((1-(2-ethyl)piperidine)-oxy)salicylidene)phenylenediaminenickel(ii) (complex (1)). For Series 1 complexes, the phenylenediamine head group of the literature complex was replaced with ethylenediamine,...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Dalton Transactions
DOI: 10.1039/c8dt02727g


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