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Accurate and rapid estimation of phosphene thresholds (REPT)

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Abrahamyan, Arman; Clifford, Colin W. G.; Ruzzoli, Manuela; Phillips, Dan; Arabzadeh, Ehsan; Harris, Justin A.

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To calibrate the intensity of transcranial magnetic stimulation (TMS) at the occipital pole, the phosphene threshold is used as a measure of cortical excitability. The phosphene threshold (PT) refers to the intensity of magnetic stimulation that induces illusory flashes of light (phosphenes) on a proportion of trials. The existing PT estimation procedures lack the accuracy and mathematical rigour of modern threshold estimation methods. We present an improved and automatic procedure for...[Show more]

dc.contributor.authorAbrahamyan, Arman
dc.contributor.authorClifford, Colin W. G.
dc.contributor.authorRuzzoli, Manuela
dc.contributor.authorPhillips, Dan
dc.contributor.authorArabzadeh, Ehsan
dc.contributor.authorHarris, Justin A.
dc.date.accessioned2015-10-21T23:35:57Z
dc.date.available2015-10-21T23:35:57Z
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1885/16019
dc.description.abstractTo calibrate the intensity of transcranial magnetic stimulation (TMS) at the occipital pole, the phosphene threshold is used as a measure of cortical excitability. The phosphene threshold (PT) refers to the intensity of magnetic stimulation that induces illusory flashes of light (phosphenes) on a proportion of trials. The existing PT estimation procedures lack the accuracy and mathematical rigour of modern threshold estimation methods. We present an improved and automatic procedure for estimating the PT which is based on the well-established Ψ Bayesian adaptive staircase approach. To validate the new procedure, we compared it with another commonly used procedure for estimating the PT. We found that our procedure is more accurate, reliable, and rapid when compared with an existing PT measurement procedure. The new procedure is implemented in Matlab and works automatically with the Magstim Rapid(2) stimulator using a convenient graphical user interface. The Matlab program is freely available for download.
dc.description.sponsorshipThis research was funded by the Australian Research Council grant DP0986137.
dc.format8 pages
dc.publisherPublic Library of Science
dc.rights© 2011 Abrahamyan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourcePLoS ONE
dc.subjectadult
dc.subjectalgorithms
dc.subjectbayes theorem
dc.subjectcalibration
dc.subjectfemale
dc.subjecthumans
dc.subjectmale
dc.subjectoccipital lobe
dc.subjectreproducibility of results
dc.subjectsensory thresholds
dc.subjecttime factors
dc.subjecttranscranial magnetic stimulation
dc.subjectyoung adult
dc.subjectphosphenes
dc.titleAccurate and rapid estimation of phosphene thresholds (REPT)
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume6
dcterms.dateAccepted2011-06-24
dc.date.issued2011-07-22
local.identifier.absfor110906
local.identifier.ariespublicationu4693331xPUB119
local.publisher.urlhttps://www.plos.org/
local.type.statusPublished Version
local.contributor.affiliationAbrahamyan, Arman, School of Psychology, The University of New South Wales, Sydney, New South Wales, Australia
local.contributor.affiliationClifford, Colin W.G., University of Sydney, Australia
local.contributor.affiliationRuzzoli, Manuela, IRCCS San Giovanni di Dio Fatebenefratelli, Italy
local.contributor.affiliationPhillips, Dan, The Magstim Company Ltd, Whitland, Wales, United Kingdom, United Kingdom
local.contributor.affiliationArabzadeh, Ehsan, College of Medicine, Biology and Environment, CMBE John Curtin School of Medical Research, Eccles Institute of Neuroscience, The Australian National University
local.contributor.affiliationHarris, Justin A, School of Psychology, The University of New South Wales, Sydney, New South Wales, Australia
dc.relationhttp://purl.org/au-research/grants/arc/DP0986137
local.identifier.essn1932-6203
local.bibliographicCitation.issue7
local.bibliographicCitation.startpagee22342
local.identifier.doi10.1371/journal.pone.0022342
dc.date.updated2015-12-08T09:45:02Z
local.identifier.scopusID2-s2.0-79960674566
CollectionsANU Research Publications

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