Differential effects of 670 and 830 nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury
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Giacci, Marcus K.; Wheeler, Lachlan; Lovett, Sarah; Dishington, Emma; Majda, Bernadette; Bartlett, Carole A.; Thornton, Emma; Harford-Wright, Elizabeth; Leonard, Anna; Vink, Robert; Harvey, Alan R.; Provis, Jan; Dunlop, Sarah A.; Hart, Nathan S.; Hodgetts, Stuart; Natoli, Riccardo; Van Den Heuvel, Corinna; Fitzgerald, Melinda
Description
Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to the clinic for treatment of neurotrauma has been hampered by lack of comparative information regarding the degree of penetration of the delivered irradiation to the injury site and the optimal treatment parameters for different CNS injuries. We compared the treatment efficacy of R/NIR-IT at 670 nm and...[Show more]
dc.contributor.author | Giacci, Marcus K. | |
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dc.contributor.author | Wheeler, Lachlan | |
dc.contributor.author | Lovett, Sarah | |
dc.contributor.author | Dishington, Emma | |
dc.contributor.author | Majda, Bernadette | |
dc.contributor.author | Bartlett, Carole A. | |
dc.contributor.author | Thornton, Emma | |
dc.contributor.author | Harford-Wright, Elizabeth | |
dc.contributor.author | Leonard, Anna | |
dc.contributor.author | Vink, Robert | |
dc.contributor.author | Harvey, Alan R. | |
dc.contributor.author | Provis, Jan | |
dc.contributor.author | Dunlop, Sarah A. | |
dc.contributor.author | Hart, Nathan S. | |
dc.contributor.author | Hodgetts, Stuart | |
dc.contributor.author | Natoli, Riccardo | |
dc.contributor.author | Van Den Heuvel, Corinna | |
dc.contributor.author | Fitzgerald, Melinda | |
dc.date.accessioned | 2015-10-21T23:26:04Z | |
dc.date.available | 2015-10-21T23:26:04Z | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/1885/16017 | |
dc.description.abstract | Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to the clinic for treatment of neurotrauma has been hampered by lack of comparative information regarding the degree of penetration of the delivered irradiation to the injury site and the optimal treatment parameters for different CNS injuries. We compared the treatment efficacy of R/NIR-IT at 670 nm and 830 nm, provided by narrow-band LED arrays adjusted to produce equal irradiance, in four in vivo rat models of CNS injury: partial optic nerve transection, light-induced retinal degeneration, traumatic brain injury (TBI) and spinal cord injury (SCI). The number of photons of 670 nm or 830 nm light reaching the SCI injury site was 6.6% and 11.3% of emitted light respectively. Treatment of rats with 670 nm R/NIR-IT following partial optic nerve transection significantly increased the number of visual responses at 7 days after injury (P ≤ 0.05); 830 nm R/NIR-IT was partially effective. 670 nm R/NIR-IT also significantly reduced reactive species and both 670 nm and 830 nm R/NIR-IT reduced hydroxynonenal immunoreactivity (P ≤ 0.05) in this model. Pre-treatment of light-induced retinal degeneration with 670 nm R/NIR-IT significantly reduced the number of Tunel+ cells and 8-hydroxyguanosine immunoreactivity (P ≤ 0.05); outcomes in 830 nm R/NIR-IT treated animals were not significantly different to controls. Treatment of fluid-percussion TBI with 670 nm or 830 nm R/NIR-IT did not result in improvements in motor or sensory function or lesion size at 7 days (P>0.05). Similarly, treatment of contusive SCI with 670 nm or 830 nm R/NIR-IT did not result in significant improvements in functional recovery or reduced cyst size at 28 days (P>0.05). Outcomes from this comparative study indicate that it will be necessary to optimise delivery devices, wavelength, intensity and duration of R/NIR-IT individually for different CNS injury types. | |
dc.description.sponsorship | This work was supported by the Neurotrauma Research Program (Western Australia) (http://www.nrp.org.au/). This project is funded through the Road Trauma Trust Account, but does not reflect views or recommendations of the Road Safety Council. NSH was funded by The University of Western Australia and The Western Australian State Government as part of a Western Australian Premiers Fellowship to Prof. Shaun Collin. | |
dc.format | 15 pages | |
dc.publisher | Public Library of Science | |
dc.rights | © 2014 Giacci et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.source | PLoS ONE | |
dc.subject | red/near-infrared irradiation therapy (R/NIR-IT) | |
dc.subject | light-emitting diode (LED) | |
dc.subject | central nervous system (CNS) injury | |
dc.subject | treatment | |
dc.subject | neurotrauma | |
dc.subject | comparative information | |
dc.subject | optimal treatment parameters | |
dc.subject | degree of penetration | |
dc.subject | irradiation | |
dc.subject | injury site | |
dc.subject | 670 nm and 830 nm | |
dc.subject | vivo rat models | |
dc.title | Differential effects of 670 and 830 nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 9 | |
dcterms.dateAccepted | 2014-07-10 | |
dc.date.issued | 2014-08-08 | |
local.identifier.absfor | 111301 | |
local.identifier.absfor | 110903 | |
local.identifier.ariespublication | u4693331xPUB140 | |
local.publisher.url | https://www.plos.org/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Giacci, Markus K, The University of Western Australia, Australia | |
local.contributor.affiliation | Wheeler, Lachlan, The University of Western Australia, Australia | |
local.contributor.affiliation | Lovett, Sarah, The University of Western Australia, Australia | |
local.contributor.affiliation | Dishington, Emma, The University of Western Australia, Australia | |
local.contributor.affiliation | Majda, Bernadette, University of Western Australia, Australia | |
local.contributor.affiliation | Bartlett, Carole A, The University of Western Australia, Australia | |
local.contributor.affiliation | Thornton, Emma, The University of Adelaide,, Australia | |
local.contributor.affiliation | Harford-Wright, Elizabeth, The University of Adelaide , Australia | |
local.contributor.affiliation | Leonard, Anna, The University of Adelaide, Australia | |
local.contributor.affiliation | Vink, Robert, The University of Adelaide, Australia | |
local.contributor.affiliation | Harvey, A.R., University of Western Australia, Australia | |
local.contributor.affiliation | Provis, Jan, College of Medicine, Biology and Environment, CMBE John Curtin School of Medical Research, Eccles Institute of Neuroscience, The Australian National University | |
local.contributor.affiliation | Dunlop, Sarah Alison, University of Western Australia, Australia | |
local.contributor.affiliation | Hart, Nathan, University of Western Australia, Australia | |
local.contributor.affiliation | Hodgetts, Stuart, The University of Western Australia, Australia | |
local.contributor.affiliation | Natoli, Riccardo, College of Medicine, Biology and Environment, CMBE John Curtin School of Medical Research, Eccles Institute of Neuroscience, The Australian National University | |
local.contributor.affiliation | Van Den Heuvel, Corinna, The University of Adelaide, Australia | |
local.contributor.affiliation | Fitzgerald, Melinda, The University of Western Australia, Australia | |
local.identifier.essn | 1932-6203 | |
local.bibliographicCitation.issue | 8 | |
local.bibliographicCitation.startpage | e104565 | |
local.bibliographicCitation.lastpage | 15 | |
local.identifier.doi | 10.1371/journal.pone.0104565 | |
dc.date.updated | 2015-12-08T10:30:01Z | |
local.identifier.scopusID | 2-s2.0-84905640324 | |
local.identifier.thomsonID | 000343231900072 | |
Collections | ANU Research Publications |
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