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Characterising the role of GABA and its metabolism in the wheat pathogen Stagonospora nodorum

Mead, Oliver; Thynne, Eli; Winterberg, Britta; Solomon, Peter S.


A reverse genetics approach was used to investigate the role of γ-aminobutyric acid metabolism in the wheat pathogenic fungus Stagonospora nodorum. The creation of mutants lacking Sdh1, the gene encoding succinic semialdehyde dehydrogenase, resulted in strains that grew poorly on γ-aminobutyric acid as a nitrogen source. The sdh1 mutants were more susceptible to reactive oxygen stress but were less affected by increased growth temperatures. Pathogenicity assays revealed that the metabolism of...[Show more]

CollectionsANU Research Publications
Date published: 2013-11-12
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0078368


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