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Distribution and severity of myopic maculopathy among highly myopic eyes

Xiao, Ou; Guo, Xinxing; Wang, Decai; Jong, Monica; Lee, Pei Ying; Chen, Linxing; Morgan, Ian; Sankaridurg, Padmaja; He, Mingguang

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Purpose The purpose of this study was to document the distribution of the severity of myopic maculopathy in a cohort of highly myopic patients and to explore the associated risk factors. Methods A total of 890 Chinese highly myopes aged between 7 and 70 years (median age 19 years) and with spherical refraction −6.00 diopter (D) or worse in both eyes were investigated. All participants underwent detailed ophthalmic examination. Myopic maculopathy was graded into 5 categories according to...[Show more]

dc.contributor.authorXiao, Ou
dc.contributor.authorGuo, Xinxing
dc.contributor.authorWang, Decai
dc.contributor.authorJong, Monica
dc.contributor.authorLee, Pei Ying
dc.contributor.authorChen, Linxing
dc.contributor.authorMorgan, Ian
dc.contributor.authorSankaridurg, Padmaja
dc.contributor.authorHe, Mingguang
dc.date.accessioned2019-04-15T12:04:28Z
dc.date.available2019-04-15T12:04:28Z
dc.identifier.issn1552-5783
dc.identifier.urihttp://hdl.handle.net/1885/159681
dc.description.abstractPurpose The purpose of this study was to document the distribution of the severity of myopic maculopathy in a cohort of highly myopic patients and to explore the associated risk factors. Methods A total of 890 Chinese highly myopes aged between 7 and 70 years (median age 19 years) and with spherical refraction −6.00 diopter (D) or worse in both eyes were investigated. All participants underwent detailed ophthalmic examination. Myopic maculopathy was graded into 5 categories according to the International Photographic Classification and Grading System using color fundus photographs: category 0, no myopic retinal lesions, category 1, tessellated fundus only; category 2, diffuse chorioretinal atrophy; category 3, patchy chorioretinal atrophy; category 4, macular atrophy. Category 2 or greater were further classified as clinically significant myopic maculopathy (CSMM). Results Data from 884 of 890 right eyes were available for analysis. The proportions of category 1, category 2, category 3, and category 4 were 20.0% (177 eyes), 20.2% (178 eyes), 2.6% (23 eyes), and 0.2% (2 eyes), respectively. The proportion of CSMM increased with more myopic refraction (odds ratio 1.57; 95% confidence interval: 1.46-1.68), longer axial length (odds ratio 2.97; 95% confidence interval: 2.50–3.53), and older age (40–70 years compared to 12–18 years, odds ratio 6.77; 95% confidence interval: 3.61–12.70). However, there was a higher proportion of CSMM in children aged 7 to 11 years than those aged 12 to 18 years (20.9% vs. 11.0%, P = 0.008). Conclusions Older age, more myopic refraction, and longer axial length were associated with more severe myopic maculopathy. Although CSMM was uncommon among younger participants, children with early-onset high myopia have a disproportionately increased risk.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherAssociation for Research in Vision and Opthalmology
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceInvestigative Ophthalmology and Visual Science
dc.titleDistribution and severity of myopic maculopathy among highly myopic eyes
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume59
dc.date.issued2018
local.identifier.absfor111301 - Ophthalmology
local.identifier.ariespublicationu4485658xPUB1364
local.type.statusPublished Version
local.contributor.affiliationXiao, Ou, Sun Yat-Sen University
local.contributor.affiliationGuo, Xinxing, Sun Yat-sen University
local.contributor.affiliationWang, Decai, Sun Yat-sen University
local.contributor.affiliationJong, Monica, University of New South Wales
local.contributor.affiliationLee, Pei Ying, University of Melbourne
local.contributor.affiliationChen, Linxing, Sun Yat-sen University
local.contributor.affiliationMorgan, Ian, College of Science, ANU
local.contributor.affiliationSankaridurg, Padmaja, Brien Holden Vision Institute
local.contributor.affiliationHe, Mingguang, Sun Yat-Sen University
local.bibliographicCitation.issue12
local.identifier.doi10.1167/iovs.18-24471
local.identifier.absseo920107 - Hearing, Vision, Speech and Their Disorders
dc.date.updated2019-03-12T07:28:50Z
local.identifier.scopusID2-s2.0-85055137909
dcterms.accessRightsOpen Access
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
CollectionsANU Research Publications

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