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Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases

Clark, Ian A; Vissel, Bryce


While cytokines such as TNF have long been recognized as essential to normal cerebral physiology, the implications of their chronic excessive production within the brain are now also increasingly appreciated. Syndromes as diverse as malaria and lead poisoning, as well as non-infectious neurodegenerative diseases, illustrate this. These cytokines also orchestrate changes in tau, α-synuclein, amyloid-β levels and degree of insulin resistance in most neurodegenerative states. New data on the...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: British Journal of Pharmacology
DOI: 10.1111/bph.14471
Access Rights: Open Access


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