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Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina

Fernando, Nilisha; Wooff, Yvette; Aggio-Bruce, Riemke; Chu-Tan, Joshua; Jiao, Haihan; Dietrich, Catherine; Rutar, Matthew; Rooke, Melissa; Menon, Deepthi; Eells, Janis T; Valter, Krisztina; Board, Philip; Provis, Jan; Natoli, Riccardo


PURPOSE. Glutathione-S-transferase omega 1-1 (GSTO1-1) is a cytosolic glutathione transferase enzyme, involved in glutathionylation, toll-like receptor signaling, and calcium channel regulation. GSTO1-1 dysregulation has been implicated in oxidative stress and inflammation, and contributes to the pathogenesis of several diseases and neurological disorders; however, its role in retinal degenerations is unknown. The aim of this study was to investigate the role of GSTO1-1 in modulating oxidative...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.18-24627
Access Rights: Open Access


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