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The meteorology of cytokine storms, and the clinical usefulness of this knowledge

Clark, Ian A; Vissel, Bryce

Description

The term cytokine storm has become a popular descriptor of the dramatic harmful consequences of the rapid release of polypeptide mediators, or cytokines, that generate inflammatory responses. This occurs throughout the body in both non-infectious and infectious disease states, including the central nervous system. In infectious disease it has become a useful concept through which to appreciate that most infectious disease is not caused directly by a pathogen, but by an overexuberant innate...[Show more]

dc.contributor.authorClark, Ian A
dc.contributor.authorVissel, Bryce
dc.date.accessioned2019-04-15T10:53:42Z
dc.identifier.issn1863-2297
dc.identifier.urihttp://hdl.handle.net/1885/159660
dc.description.abstractThe term cytokine storm has become a popular descriptor of the dramatic harmful consequences of the rapid release of polypeptide mediators, or cytokines, that generate inflammatory responses. This occurs throughout the body in both non-infectious and infectious disease states, including the central nervous system. In infectious disease it has become a useful concept through which to appreciate that most infectious disease is not caused directly by a pathogen, but by an overexuberant innate immune response by the host to its presence. It is less widely known that in addition to these roles in disease pathogenesis these same cytokines are also the basis of innate immunity, and in lower concentrations have many essential physiological roles. Here we update this field, including what can be learned through the history of how these interlinking three aspects of biology and disease came to be appreciated. We argue that understanding cytokine storms in their various degrees of acuteness, severity and persistence is essential in order to grasp the pathophysiology of many diseases, and thus the basis of newer therapeutic approaches to treating them. This particularly applies to the neurodegenerative diseases.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherSpringer
dc.sourceSeminars in Immunopathology
dc.titleThe meteorology of cytokine storms, and the clinical usefulness of this knowledge
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume39
dc.date.issued2017
local.identifier.absfor111502 - Clinical Pharmacology and Therapeutics
local.identifier.ariespublicationu4485658xPUB1170
local.type.statusPublished Version
local.contributor.affiliationClark, Ian A, College of Science, ANU
local.contributor.affiliationVissel, Bryce, Garvan Institute of Medical Research
local.description.embargo2040-01-01
local.bibliographicCitation.issue5
local.identifier.doi10.1007/s00281-017-0628-y
local.identifier.absseo920112 - Neurodegenerative Disorders Related to Ageing
local.identifier.absseo920111 - Nervous System and Disorders
dc.date.updated2019-03-12T07:28:18Z
local.identifier.scopusID2-s2.0-85018331636
local.identifier.thomsonID000404604900002
dc.provenanceJournal: Seminars in Immunopathology (ISSN: 1863-2297, ESSN: 1863-2300) RoMEO: This is a RoMEO green journal Paid OA: A paid open access option is available for this journal. Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF
CollectionsANU Research Publications

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