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Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption

Lawrence, Nicole; Dennis, Adelaide; Lehane, Adele; Ehmann, Anna; Harvey, Peta J.; Benfield, Aurelie H.; Cheneval, Olivier; Henriques, Sonia Troeira; Craik, David J.; McMorran, Brendan


Malaria is a serious threat to human health and additional classes of antimalarial drugs are greatly needed. The human defense protein, platelet factor 4 (PF4), has intrinsic antiplasmodial activity but also undesirable chemokine properties. We engineered a peptide containing the isolated PF4 antiplasmodial domain, which through cyclization, retained the critical structure of the parent protein. The peptide, cPF4PD, killed cultured blood-stage Plasmodium falciparum with low micromolar potency...[Show more]

CollectionsANU Research Publications
Date published: 2018-09-20
Type: Journal article
Source: Cell Chemical Biology
DOI: 10.1016/j.chembiol.2018.06.009
Access Rights: Open Access


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