Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption
Malaria is a serious threat to human health and additional classes of antimalarial drugs are greatly needed. The human defense protein, platelet factor 4 (PF4), has intrinsic antiplasmodial activity but also undesirable chemokine properties. We engineered a peptide containing the isolated PF4 antiplasmodial domain, which through cyclization, retained the critical structure of the parent protein. The peptide, cPF4PD, killed cultured blood-stage Plasmodium falciparum with low micromolar potency...[Show more]
|Collections||ANU Research Publications|
|Source:||Cell Chemical Biology|
|Access Rights:||Open Access|
|Lawrence 2018 - unformated preprint.pdf||2.22 MB||Adobe PDF|
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