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Diverse antimalarials from wholecell phenotypic screens disrupt malaria parasite ion and volume homeostasis

Dennis, Adelaide; Rosling, James; Lehane, Adele; Kirk, Kiaran


Four hundred structurally diverse drug-like compounds comprising the Medicines for Malaria Venture’s ‘Pathogen Box’ were screened for their effect on a range of physiological parameters in asexual blood-stage malaria (Plasmodium falciparum) parasites. Eleven of these compounds were found to perturb parasite Na+, pH and volume in a manner consistent with inhibition of the putative Na+ efflux P-type ATPase PfATP4. All eleven compounds fell within the subset of 125 compounds included in the...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Scientific Reports
DOI: 10.1038/s41598-018-26819-1
Access Rights: Open Access


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