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Quantitative Polymerase Chain Reaction for Diagnosis of Soil-Transmitted Helminth Infections: A Comparison with a Flotation-Based Technique and an Investigation of Variability in DNA Detection

Clarke, Naomi; Llewellyn, Stacey; Traub, Rebecca; McCarthy, James; Richardson, Alice; Vaz da Silva de Castro Nery, Susana


Appropriate diagnostic techniques are crucial to global soil-transmitted helminth (STH) control efforts. The recommended Kato–Katz method has low sensitivity in low-transmission settings. Quantitative polymerase chain reaction (qPCR) is a highly sensitive alternative diagnostic option. However, little is known about the variability in qPCR results, and there are few published comparisons between qPCR and other microscopy-based techniques such as sodium nitrate flotation (SNF). Using 865...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: American Journal of Tropical Medicine and Hygiene
DOI: 10.4269/ajtmh.18-0356


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