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Phase I trial of Lipovaxin-MM, a novel dendritic cell-targeted liposomal vaccine for malignant melanoma

Gargett, T; Abbas, MN; Rolan, P; Price, Jason D; Gosling, Katharine M; Ferrante, A; Ruszkiewicz, A; Atmosukarto, Ines I C; Altin, Joseph; Parish, Christopher; Brown, MP

Description

INTRODUCTION: In this phase I study using a 3 + 3 dose escalation design, the safety, dose-limiting toxicity (DLT), immunogenicity and efficacy of intravenous Lipovaxin-MM-a multi-component dendritic cell-targeted liposomal vaccine against metastatic melanoma-was investigated. METHODS: Twelve subjects with metastatic cutaneous melanoma were recruited in three cohorts. Patients in Cohort A (n = 3) and Cohort B (n = 3) received three doses of 0.1 and 1 mL of Lipovaxin-MM, respectively,...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/159461
Source: Cancer Immunology, Immunotherapy
DOI: 10.1007/s00262-018-2207-z

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