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Melanoma protective anti-tumor immunity activated by catalytic DNA

Cai, Hong; Cho, Eun-Ae; Li, Yue; Sockler, Jim; Parish, Christopher; Chong, Beng; Edwards, Jarem; Dodds, Tristan J; Ferguson, Peter M; Wilmott, James S.; Scolyer, Richard A.

Description

Melanoma incidence is increasing worldwide, and although drugs such as BRAF/MEK small-molecule inhibitors and immune checkpoint antibodies improve patient outcomes, most patients ultimately fail these therapies and alternative treatment strategies are urgently needed. DNAzymes have recently undergone clinical trials with signs of efficacy and no serious adverse events attributable to the DNAzyme. Here we investigated c-Jun expression in human primary and metastatic melanoma. We also explored...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/159460
Source: Oncogene
DOI: 10.1038/s41388-018-0306-0

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