The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
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Vince, James E; De Nardo, Dominic; Gao, Wenqing; Vince, Angelina J.; Hall, Cathrine; McArthur, Kate; Simpson, Daniel; Vijayaraj, Swarna; Lindqvist, Lisa M.; Bouillet, Philippe; Rizzacasa, Mark A.; Man, Si Ming; Silke, John; Masters, Seth; Lessene, Guillaume; Huang, David C.S.; Gray, Daniel H.D.; Kile, B.T.; Shao, Feng; Lawlor, Kate E.
Description
Intrinsic apoptosis resulting from BAX/BAK-mediated mitochondrial membrane damage is regarded as immunologically silent. We show here that in macrophages, BAX/BAK activation results in inhibitor of apoptosis (IAP) protein degradation to promote caspase-8-mediated activation of IL-1β. Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1β maturation that requires potassium efflux. Remarkably, following BAX/BAK activation, the apoptotic...[Show more]
dc.contributor.author | Vince, James E | |
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dc.contributor.author | De Nardo, Dominic | |
dc.contributor.author | Gao, Wenqing | |
dc.contributor.author | Vince, Angelina J. | |
dc.contributor.author | Hall, Cathrine | |
dc.contributor.author | McArthur, Kate | |
dc.contributor.author | Simpson, Daniel | |
dc.contributor.author | Vijayaraj, Swarna | |
dc.contributor.author | Lindqvist, Lisa M. | |
dc.contributor.author | Bouillet, Philippe | |
dc.contributor.author | Rizzacasa, Mark A. | |
dc.contributor.author | Man, Si Ming | |
dc.contributor.author | Silke, John | |
dc.contributor.author | Masters, Seth | |
dc.contributor.author | Lessene, Guillaume | |
dc.contributor.author | Huang, David C.S. | |
dc.contributor.author | Gray, Daniel H.D. | |
dc.contributor.author | Kile, B.T. | |
dc.contributor.author | Shao, Feng | |
dc.contributor.author | Lawlor, Kate E. | |
dc.date.accessioned | 2019-04-10T11:29:05Z | |
dc.date.available | 2019-04-10T11:29:05Z | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | http://hdl.handle.net/1885/159457 | |
dc.description.abstract | Intrinsic apoptosis resulting from BAX/BAK-mediated mitochondrial membrane damage is regarded as immunologically silent. We show here that in macrophages, BAX/BAK activation results in inhibitor of apoptosis (IAP) protein degradation to promote caspase-8-mediated activation of IL-1β. Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1β maturation that requires potassium efflux. Remarkably, following BAX/BAK activation, the apoptotic executioner caspases, caspase-3 and -7, act upstream of both caspase-8 and NLRP3-induced IL-1β maturation and secretion. Conversely, the pyroptotic cell death effectors gasdermin D and gasdermin E are not essential for BAX/BAK-induced IL-1β release. These findings highlight that innate immune cells undergoing BAX/BAK-mediated apoptosis have the capacity to generate pro-inflammatory signals and provide an explanation as to why IL-1β activation is often associated with cellular stress, such as during chemotherapy. | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | Elsevier Inc. | |
dc.rights | Elsevier | |
dc.source | Cell Reports | |
dc.title | The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 25 | |
dc.date.issued | 2018 | |
local.identifier.absfor | 110707 - Innate Immunity | |
local.identifier.ariespublication | u1036742xPUB47 | |
local.type.status | Published Version | |
local.contributor.affiliation | Vince, James E, The Walter and Eliza Hall Institute of Medical Research | |
local.contributor.affiliation | De Nardo, Dominic, The Walter and Eliza Hall Institute of Medical Research | |
local.contributor.affiliation | Gao, Wenqing, National Institute of Biological Sciences, Beijing 102206, China | |
local.contributor.affiliation | Vince, Angelina J. , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Hall, Cathrine , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | McArthur, Kate , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Simpson, Daniel , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Vijayaraj, Swarna , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Lindqvist, Lisa M. , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Bouillet, Philippe , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Rizzacasa, Mark A. , School of Chemistry, The Bio 21 Institute, The University of Melbourne, Melbourne, VIC 3010, Australia | |
local.contributor.affiliation | Man, Si Ming, College of Health and Medicine, ANU | |
local.contributor.affiliation | Silke, John , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Masters, Seth, Walter and Eliza Hall Institute of Medical Research | |
local.contributor.affiliation | Lessene, Guillaume , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Huang, David C.S. , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Gray, Daniel H.D. , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.contributor.affiliation | Kile, B.T., Walter & Eliza Hall Institute of Medical Research | |
local.contributor.affiliation | Shao, Feng, National Institute of Biological Sciences, Beijing 102206, China | |
local.contributor.affiliation | Lawlor, Kate E. , The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia | |
local.bibliographicCitation.issue | 9 | |
local.identifier.doi | 10.1016/j.celrep.2018.10.103 | |
local.identifier.absseo | 920108 - Immune System and Allergy | |
dc.date.updated | 2019-03-12T07:23:56Z | |
local.identifier.scopusID | 2-s2.0-85056715707 | |
dcterms.accessRights | Open Access | |
dc.provenance | Journal: Cell Reports [1] (ISSN: 2211-1247, ESSN: 2211-1247) [This title is Open Access] RoMEO: This is a RoMEO green journal Listed in: DOAJ as an open access journal Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: green tick author can archive publisher's version/PDF | |
Collections | ANU Research Publications |
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